Poly(ADP-Ribose) Polymerase-Deficient Mice Are Protected from Streptozotocin-Induced Diabetes
Poly(ADP-Ribose) Polymerase-Deficient Mice Are Protected from Streptozotocin-Induced Diabetes
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United States: National Academy of Sciences of the United States of America
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Language
English
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United States: National Academy of Sciences of the United States of America
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Streptozotocin (STZ) selectivity destroys insulin-producing beta islet cells of the pancreas providing a model of type I diabetes. Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme whose overactivation by DNA strand breaks depletes its substrate NAD+and then ATP, leading to cellular death from energy depletion. We demonstrate DNA damage and a...
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Full title
Poly(ADP-Ribose) Polymerase-Deficient Mice Are Protected from Streptozotocin-Induced Diabetes
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TN_cdi_proquest_journals_201374965
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201374965
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.96.6.3059
