Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the req...
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Tumor cell proliferation requires rapid synthesis of macromolecules including lipids, proteins, and nucleotides. Many tumor cells exhibit rapid glucose consumption, with most of the glucose-derived carbon being secreted as lactate despite abundant oxygen availability (the Warburg effect). Here, we used ¹³C NMR spectroscopy to examine the metabolism...
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Full title
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
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TN_cdi_proquest_journals_201403195
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201403195
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0709747104
