progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome or...
progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Numerous mutations in the human A-type lamin gene (LMNA) cause the premature aging disease, progeria. Some of these are located in the α-helical central rod domain required for the polymerization of the nuclear lamins into higher order structures. Patient cells with a mutation in this domain, 433G>A (E145K) show severely lobulated nuclei, a separat...
Alternative Titles
Full title
progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization
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Record Identifier
TN_cdi_proquest_journals_201406324
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201406324
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0911895106
