p53 Accumulates but is Functionally Impaired when DNA Synthesis is Blocked
p53 Accumulates but is Functionally Impaired when DNA Synthesis is Blocked
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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p53 is required for the induction of a G1and/or G2irreversible arrest after γ irradiation (IR), whereas blocked DNA replication causes a p53-independent S-phase arrest. We have examined the response to p53 when DNA synthesis is blocked by hydroxyurea (HU) or aphidicolin or when DNA is damaged by γ IR. Similarly to γ IR, blocked DNA synthesis induce...
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Full title
p53 Accumulates but is Functionally Impaired when DNA Synthesis is Blocked
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TN_cdi_proquest_journals_201412705
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201412705
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.98.3.1036
