Disulfide Isomerization Switches Tissue Factor from Coagulation to Cell Signaling
Disulfide Isomerization Switches Tissue Factor from Coagulation to Cell Signaling
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Cell-surface tissue factor (TF) binds the serine protease factor Vila to activate coagulation or, alternatively, to trigger signaling through the G protein-coupled, protease-activated receptor 2 (PAR2) relevant to inflammation and angiogenesis. Here we demonstrate that TF.Vlla-mediated coagulation and cell signaling involve distinct cellular pools...
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Full title
Disulfide Isomerization Switches Tissue Factor from Coagulation to Cell Signaling
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TN_cdi_proquest_journals_201413690
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201413690
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0606411103
