Rare cancer-specific mutations in PIK3CA show gain of function
Rare cancer-specific mutations in PIK3CA show gain of function
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Fifteen rare cancer-derived mutants of PIK3CA, the gene coding for the catalytic subunit p110α of phosphatidylinositol 3-kinase (PI3K), were examined for their biological and biochemical properties. Fourteen of these mutants show a gain of function: they induce rapamycin-sensitive oncogenic transformation of chicken embryo fibroblasts, constitutive...
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Full title
Rare cancer-specific mutations in PIK3CA show gain of function
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Record Identifier
TN_cdi_proquest_journals_201418079
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201418079
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0701005104
