Members of the PIAS Family Act as SUMO Ligases for c-Jun and p53 and Repress p53 Activity
Members of the PIAS Family Act as SUMO Ligases for c-Jun and p53 and Repress p53 Activity
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The activity of the p53 tumor suppressor protein and the c-Jun protooncogene is regulated by posttranslational modifications, such as phosphorylation or ubiquitination. In addition, covalent attachment of the ubiquitin-like modifier SUMO appears to modulate their transcriptional activity. Sumoylation proceeds via an enzymatic pathway that is mechan...
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Members of the PIAS Family Act as SUMO Ligases for c-Jun and p53 and Repress p53 Activity
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TN_cdi_proquest_journals_201418586
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201418586
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.052559499
