Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease k...
Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Cognitive problems occur in asymptomatic gene carriers of Huntington's disease (HD), and mouse models of the disease exhibit impaired learning and substantial deficits in the cytoskeletal changes that stabilize long-term potentiation (LTP). The latter effects may be related to the decreased production of brain-derived neurotrophic factor (BDNF) ass...
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Full title
Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice
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TN_cdi_proquest_journals_201419169
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201419169
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0811228106
