Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated c...
Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The expression of ASPP2 (53BP2L), a proapoptotic member of a family of p53-binding proteins, is frequently suppressed in many human cancers. Accumulating evidence suggests that ASPP2 inhibits tumor growth; however, the mechanisms by which ASPP2 suppresses tumor formation remain to be clarified. To study this, we targeted the ASPP2 allele in a mouse...
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Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds
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TN_cdi_proquest_journals_201427198
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201427198
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0809080106
