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Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-cano...

Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-cano...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201432211

Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38[alpha] MAPK pathway

About this item

Full title

Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38[alpha] MAPK pathway

Publisher

Washington: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (9), p.4188

Language

English

Formats

Publication information

Publisher

Washington: National Academy of Sciences

More information

Scope and Contents

Contents

Patients with primary (AL) cardiac amyloidosis suffer from progressive cardiomyopathy with a median survival of less than 8 months and a 5-year survival of <10%. Contributing to this poor prognosis is the fact that these patients generally do not tolerate standard heart failure therapies. The molecular mechanisms underlying this deadly form of hear...

Alternative Titles

Full title

Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38[alpha] MAPK pathway

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_201432211

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201432211

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

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