Implications of TERT promoter mutations and telomerase activity in urothelial carcinogenesis
Implications of TERT promoter mutations and telomerase activity in urothelial carcinogenesis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Telomerase activity imparts eukaryotic cells with unlimited proliferation capacity, one of the cancer hallmarks. Over 90% of human urothelial carcinoma of the bladder (UCB) tumours are positive for telomerase activity. Telomerase activation can occur through several mechanisms. Mutations in the core promoter region of the human telomerase reverse t...
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Implications of TERT promoter mutations and telomerase activity in urothelial carcinogenesis
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TN_cdi_proquest_journals_2047878726
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2047878726
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ISSN
1759-4812
E-ISSN
1759-4820
DOI
10.1038/s41585-018-0001-5
