Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Mod...
Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
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Author / Creator
Giadone, Richard M , Liberti, Derek C , Matte, Taylor M , Rosarda, Jessica D , Torres-Arancivia, Celia , Ghosh, Sabrina , Diedrich, Jolene K , Pankow, Sandra , Skvir, Nicholas , Jyh-Chang, Jean , Yates, John R , Wilson, Andrew A , Connors, Lawreen H , Kotton, Darrell N , R Luke Wiseman and Murphy, George J
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Systemic amyloidosis represents a class of disorders in which misfolded proteins are secreted by effector organs and deposited as proteotoxic aggregates at downstream target tissues. Despite being well-described clinically, the contribution of effector organs such as the liver to the pathogenesis of these diseases is poorly understood. Here, we uti...
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Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
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TN_cdi_proquest_journals_2068563672
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2068563672
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E-ISSN
2692-8205
DOI
10.1101/358515
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https://www.proquest.com/docview/2068563672?pq-origsite=primo&accountid=13902
