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The expression of class II major histocompatibility molecules on breast tumors delays T cell exhaust...

The expression of class II major histocompatibility molecules on breast tumors delays T cell exhaust...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2068831109

The expression of class II major histocompatibility molecules on breast tumors delays T cell exhaustion, expands the T cell repertoire and slows tumor growth

About this item

Full title

The expression of class II major histocompatibility molecules on breast tumors delays T cell exhaustion, expands the T cell repertoire and slows tumor growth

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2018-04

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

The expression of major histocompatibility complex II (MHCII) on tumor cells correlates with survival and responsiveness to immunotherapy. However, the mechanisms underlying these observations are poorly defined. Using a murine breast tumor line, we tested how MHCII expression affected anti-tumor immunity. We found that MHCII-expressing tumors grew...

Alternative Titles

Full title

The expression of class II major histocompatibility molecules on breast tumors delays T cell exhaustion, expands the T cell repertoire and slows tumor growth

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2068831109

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2068831109

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/294124