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Cell-cell contact dictates life or death decisions following CD95 activation in cancer

Cell-cell contact dictates life or death decisions following CD95 activation in cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2068835073

Cell-cell contact dictates life or death decisions following CD95 activation in cancer

About this item

Full title

Cell-cell contact dictates life or death decisions following CD95 activation in cancer

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2018-04

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Cancer cells react to CD95 activation with either apoptotic or tumorigenic responses. Yet, the determinants of these two antithetic reactions are fundamentally not understood. Here, we show that pre-confined CD95L molecules activate apoptosis of cancer cells in-vitro. For particular CD95L pre-confinement, apoptosis activation is most efficient. Sur...

Alternative Titles

Full title

Cell-cell contact dictates life or death decisions following CD95 activation in cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2068835073

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2068835073

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/308346