Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress
Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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The mechanisms used by cancer cells to resist the severe disruption in protein homeostasis caused by proteasome inhibitors remain obscure. Here, we show this resistance correlates with a metabolic shift from glycolysis to oxidative phosphorylation (OXPHOS). Employing small molecule screens, we identified a striking overlap between compounds that pr...
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Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress
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TN_cdi_proquest_journals_2068974380
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2068974380
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E-ISSN
2692-8205
DOI
10.1101/288365
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https://www.proquest.com/docview/2068974380?pq-origsite=primo&accountid=13902
