T cell co-stimulatory receptor CD28 is a primary target for PD-1-mediated inhibition
T cell co-stimulatory receptor CD28 is a primary target for PD-1-mediated inhibition
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Programmed death-1 (PD-1) is a co-inhibitory receptor that suppresses T cell activation and is an important cancer immunotherapy target. Upon activation by its ligand PD-L1, PD-1 is thought to suppress signaling through the T cell receptor (TCR). Here, by titrating the strength of PD-1 signaling in both biochemical reconstitution systems and in T c...
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Full title
T cell co-stimulatory receptor CD28 is a primary target for PD-1-mediated inhibition
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TN_cdi_proquest_journals_2070368255
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2070368255
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E-ISSN
2692-8205
DOI
10.1101/086652
How to access this item
https://www.proquest.com/docview/2070368255?pq-origsite=primo&accountid=13902
