Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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4-Anilinoquinolines were identified as potent and narrow spectrum inhibitors of the cyclin G associated kinase (GAK), an important regulator of viral and bacterial entry into host cells. Optimization of the 4-anilino group and the 6,7-quinoline substituents produced GAK inhibitors with nanomolar activity and over 50,000-fold selectivity relative to...
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Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
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TN_cdi_proquest_journals_2070386580
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2070386580
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E-ISSN
2692-8205
DOI
10.1101/117630
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https://www.proquest.com/docview/2070386580?pq-origsite=primo&accountid=13902
