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phospho-ERK is a response biomarker to a combination of sorafenib and MEK inhibition in liver cancer

phospho-ERK is a response biomarker to a combination of sorafenib and MEK inhibition in liver cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2071127218

phospho-ERK is a response biomarker to a combination of sorafenib and MEK inhibition in liver cancer

About this item

Full title

phospho-ERK is a response biomarker to a combination of sorafenib and MEK inhibition in liver cancer

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2018-01

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Treatment of liver cancer remains challenging, due to a paucity of drugs that target critical dependencies. Sorafenib is a multikinase inhibitor that is approved as the standard therapy for advanced hepatocellular carcinoma patients, but it can only provide limited survival benefit for patients. To investigate the cause of this limited therapeutic...

Alternative Titles

Full title

phospho-ERK is a response biomarker to a combination of sorafenib and MEK inhibition in liver cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2071127218

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2071127218

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/252452