Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that...
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airways
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Author / Creator
Miner, Kent , Labitzke, Katja , Liu, Benxian , Wang, Paul , Henckels, Kathryn , Gaida, Kevin , Elliott, Robin , Chen, Jian Jeffrey , Liu, Longbin , Leith, Anh , Trueblood, Esther , Hensley, Kelly , Xing-Zhong Xia , Homann, Oliver , Bennett, Brian , Fiorino, Mike , Whoriskey, John , Yu, Gang , Escobar, Sabine , Wong, Min , Born, Teresa L , Budelsky, Alison , Comeau, Mike , Smith, Dirk , Phillips, Jonathan , Johnston, James A , Mcgivern, Joe , Weikl, Kerstin , Powers, David , Kunzelmann, Karl , Mohn, Deanna , Hochheimer, Andreas and Sullivan, John K
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor beta-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. Antagonists of the calcium-activated chloride channel, TMEM16A, offers a new mechanism to bronchodilate airways and block the multiple contractiles operating in severe disease....
Alternative Titles
Full title
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airways
Authors, Artists and Contributors
Author / Creator
Labitzke, Katja
Liu, Benxian
Wang, Paul
Henckels, Kathryn
Gaida, Kevin
Elliott, Robin
Chen, Jian Jeffrey
Liu, Longbin
Leith, Anh
Trueblood, Esther
Hensley, Kelly
Xing-Zhong Xia
Homann, Oliver
Bennett, Brian
Fiorino, Mike
Whoriskey, John
Yu, Gang
Escobar, Sabine
Wong, Min
Born, Teresa L
Budelsky, Alison
Comeau, Mike
Smith, Dirk
Phillips, Jonathan
Johnston, James A
Mcgivern, Joe
Weikl, Kerstin
Powers, David
Kunzelmann, Karl
Mohn, Deanna
Hochheimer, Andreas
Sullivan, John K
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2071127237
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2071127237
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/254888
How to access this item
https://www.proquest.com/docview/2071127237?pq-origsite=primo&accountid=13902
