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Capturing the onset of PRC2-mediated repressive domain formation

Capturing the onset of PRC2-mediated repressive domain formation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2071169170

Capturing the onset of PRC2-mediated repressive domain formation

About this item

Full title

Capturing the onset of PRC2-mediated repressive domain formation

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2018-02

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Polycomb repressive complex 2 (PRC2) maintains gene silencing by catalyzing methylation of histone H3 at lysine 27 (H3K27me2/3) within chromatin. By designing a system whereby PRC2-mediated repressive domains were collapsed and then reconstructed in an inducible fashion in vivo, a two-step mechanism of H3K27me2/3 domain formation became evident. Fi...

Alternative Titles

Full title

Capturing the onset of PRC2-mediated repressive domain formation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2071169170

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2071169170

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/272989