Capturing the onset of PRC2-mediated repressive domain formation
Capturing the onset of PRC2-mediated repressive domain formation
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Polycomb repressive complex 2 (PRC2) maintains gene silencing by catalyzing methylation of histone H3 at lysine 27 (H3K27me2/3) within chromatin. By designing a system whereby PRC2-mediated repressive domains were collapsed and then reconstructed in an inducible fashion in vivo, a two-step mechanism of H3K27me2/3 domain formation became evident. Fi...
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Capturing the onset of PRC2-mediated repressive domain formation
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TN_cdi_proquest_journals_2071169170
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2071169170
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E-ISSN
2692-8205
DOI
10.1101/272989
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https://www.proquest.com/docview/2071169170?pq-origsite=primo&accountid=13902