Aging and neurodegeneration are associated with increased mutations in single human neurons
Aging and neurodegeneration are associated with increased mutations in single human neurons
About this item
Full title
Author / Creator
Lodato, Michael A , Rodin, Rachel E , Bohrson, Craig L , Coulter, Michael E , Barton, Alison R , Kwon, Minseok , Sherman, Maxwell A , Vitzhum, Carl M , Luquette, Lovelace J , Yandava, Chandri , Yang, Pengwei , Chittenden, Thomas W , Hatem, Nicole E , Ryu, Steven C , Woodworth, Mollie B , Park, Peter J and Walsh, Christopher A
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
It has long been hypothesized that aging and neurodegeneration are associated with somatic mutation in neurons; however, methodological hurdles have prevented testing this hypothesis directly. We used single-cell whole-genome sequencing to perform genome-wide somatic single-nucleotide variant (sSNV) identification on DNA from 161 single neurons fro...
Alternative Titles
Full title
Aging and neurodegeneration are associated with increased mutations in single human neurons
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2071241830
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2071241830
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/221960
How to access this item
https://www.proquest.com/docview/2071241830?pq-origsite=primo&accountid=13902
