Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhi...
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
About this item
Full title
Author / Creator
Pettitt, Stephen J , Krastev, Dragomir B , Brandsma, Inger , Drean, Amy , Song, Feifei , Aleksandrov, Radoslav , Harrell, Maria I , Menon, Malini , Brough, Rachel , Campbell, James , Frankum, Jessica , Ranes, Michael , Pemberton, Helen N , Rafiq, Rumana , Fenwick, Kerry , Swain, Amanda , Guettler, Sebastian , Jung-Min, Lee , Swisher, Elizabeth M , Stoynov, Stoyno , Yusa, Kosuke , Ashworth, Alan and Lord, Christopher J
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
PARP inhibitors (PARPi) target homologous recombination defective tumour cells via synthetic lethality. Genome-wide and high-density CRISPR-Cas9 "tag, mutate and enrich" mutagenesis screens identified single amino acid mutations in PARP1 that cause profound PARPi-resistance. These included PARP1 mutations outside of the DNA interacting regions of t...
Alternative Titles
Full title
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
Authors, Artists and Contributors
Author / Creator
Krastev, Dragomir B
Brandsma, Inger
Drean, Amy
Song, Feifei
Aleksandrov, Radoslav
Harrell, Maria I
Menon, Malini
Brough, Rachel
Campbell, James
Frankum, Jessica
Ranes, Michael
Pemberton, Helen N
Rafiq, Rumana
Fenwick, Kerry
Swain, Amanda
Guettler, Sebastian
Jung-Min, Lee
Swisher, Elizabeth M
Stoynov, Stoyno
Yusa, Kosuke
Ashworth, Alan
Lord, Christopher J
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2071250170
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2071250170
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/203224
How to access this item
https://www.proquest.com/docview/2071250170?pq-origsite=primo&accountid=13902
