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Immune-active microenvironment in small cell carcinoma of the ovary, hypercalcemic type: rationale f...

Immune-active microenvironment in small cell carcinoma of the ovary, hypercalcemic type: rationale f...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2071251844

Immune-active microenvironment in small cell carcinoma of the ovary, hypercalcemic type: rationale for immune checkpoint blockade

About this item

Full title

Immune-active microenvironment in small cell carcinoma of the ovary, hypercalcemic type: rationale for immune checkpoint blockade

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2017-10

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a highly aggressive monogenic cancer driven by SMARCA4 mutations. Here, we report responses to anti-PD1 immunotherapy in four patients and characterize the immune landscape of SCCOHT tumors using quantitative immunofluorescence and gene expression profiling. Unexpectedly for a low mu...

Alternative Titles

Full title

Immune-active microenvironment in small cell carcinoma of the ovary, hypercalcemic type: rationale for immune checkpoint blockade

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2071251844

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2071251844

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/197970