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Dimerisation of APOBEC1 is dispensable for its RNA/DNA editing activity and modulates its availabili...

Dimerisation of APOBEC1 is dispensable for its RNA/DNA editing activity and modulates its availabili...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2100098960

Dimerisation of APOBEC1 is dispensable for its RNA/DNA editing activity and modulates its availability

About this item

Full title

Dimerisation of APOBEC1 is dispensable for its RNA/DNA editing activity and modulates its availability

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2021-02

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

ABSTRACT The AID/APOBECs are DNA/RNA deaminases whose mutagenic activity has been linked to cancer. Among them, APOBEC1 physiologically partakes into a complex that edits a CAA codon into UAA Stop codon in the transcript of Apolipoprotein B (APOB), a protein crucial in the transport of lipids in the blood. Catalytically inactive mutants of APOBEC1...

Alternative Titles

Full title

Dimerisation of APOBEC1 is dispensable for its RNA/DNA editing activity and modulates its availability

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2100098960

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2100098960

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/410803