Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity
Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity
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United States: Elsevier Inc
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Language
English
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United States: Elsevier Inc
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Cytochrome P450s metabolize the naturally occurring nephrotoxin aristolochic acid. Using liver-specific cytochrome P450 reductase-null mice we found that a low but lethal dose of aristolochic acid I was ineffective in wild-type mice. Induction of hepatic CYP1A by 3-methylcholanthrene pretreatment markedly increased the survival rate of wild type mi...
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Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity
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TN_cdi_proquest_journals_210117490
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_210117490
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ISSN
0085-2538
E-ISSN
1523-1755
DOI
10.1038/ki.2008.103
