HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
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Di Rita, Anthea , Peschiaroli, Angelo , D′Acunzo, Pasquale , Strobbe, Daniela , Hu, Zehan , Gruber, Jens , Nygaard, Mads , Lambrughi, Matteo , Melino, Gerry , Papaleo, Elena , Dengjel, Jörn , El Alaoui, Said , Campanella, Michelangelo , Dötsch, Volker , Rogov, Vladimir V. , Strappazzon, Flavie and Cecconi, Francesco
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 regulator-1) has been defined as a novel regulator of mitophagy in both PINK1/PARKIN-dependent and -ind...
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Full title
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
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TN_cdi_proquest_journals_2104154330
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2104154330
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05722-3
