A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis
A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Mechanisms that limit thrombosis are poorly defined. One of the few known endogenous platelet inhibitors is nitric oxide (NO). NO activates NO sensitive guanylyl cyclase (NO-GC) in platelets, resulting in an increase of cyclic guanosine monophosphate (cGMP). Here we show, using cGMP sensor mice to study spatiotemporal dynamics of platelet cGMP, tha...
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Full title
A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis
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TN_cdi_proquest_journals_2120718152
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2120718152
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06638-8
