A therapeutic approach to pantothenate kinase associated neurodegeneration
A therapeutic approach to pantothenate kinase associated neurodegeneration
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Pantothenate kinase (PANK) is a metabolic enzyme that regulates cellular coenzyme A (CoA) levels. There are three human
PANK
genes, and inactivating mutations in
PANK2
lead to pantothenate kinase associated neurodegeneration (PKAN). Here we performed a library screen followed by chemical optimization to produce PZ-2891, an allosteric PA...
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Full title
A therapeutic approach to pantothenate kinase associated neurodegeneration
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TN_cdi_proquest_journals_2124454006
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2124454006
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06703-2
