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Advances of Tissue Factor in Lung Cancer

Advances of Tissue Factor in Lung Cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2127325671

Advances of Tissue Factor in Lung Cancer

About this item

Full title

Advances of Tissue Factor in Lung Cancer

Author / Creator

Publisher

Tianjin: Chinese Anti-Cancer Association Chinese Antituberculosis Association

Journal title

Zhongguo fei ai za zhi, 2010-09, Vol.13 (9)

Language

Chinese

Formats

Publication information

Publisher

Tianjin: Chinese Anti-Cancer Association Chinese Antituberculosis Association

More information

Scope and Contents

Contents

早在150多年前就有人提出恶性肿瘤患者容易出现高凝血状态,若血栓形成可能导致致命性并发症的发生。近年来恶性肿瘤和机体凝血系统的研究表明肿瘤不仅可以激活机体的凝血系统,而且后者参与肿瘤的恶性生物学行为。肺癌是目前世界范围内发病率和死亡率最高的肿瘤之一,组织因子作为机体凝血系统的重要始动因子,两者存在密切的关系。本文重点对肺癌中组织因子(tissue factor, TF)的表达以及在肺癌生长和转移中作用机制等加以综述。 1 TF的结构特征 TF的基因位于染色体1p21-1p22,总长度12.4 kb,含6个外显子所转录的mRNA为2.1 kb,最终翻译修饰的TF位于细胞表面相对分子量为47 kDa的一单链跨膜糖蛋白,属于二级细胞因子受体家族。它由263个氨基酸残基组成,分为含有可溶性的氨基末端...

Alternative Titles

Full title

Advances of Tissue Factor in Lung Cancer

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2127325671

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2127325671

Other Identifiers

ISSN

1009-3419

E-ISSN

1999-6187

DOI

10.3779/cjlc.v13i9.1408

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