Alleviation of side effects induced by irinotecan hydrochloride (CPT-11) in rats by intravenous infu...
Alleviation of side effects induced by irinotecan hydrochloride (CPT-11) in rats by intravenous infusion
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Publisher
Berlin: Springer
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Language
English
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Publisher
Berlin: Springer
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Contents
Irinotecan hydrochloride (CPT-11) is a potent topoisomerase I inhibitor and is established and used widely as an antitumor agent. However, it sometimes causes severe side effects such as myelosuppression and diarrhea. These dose-limiting toxicities prevent the adoption of CPT-11 in aggressive chemotherapy. Thus we sought to determine in a rat model...
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Full title
Alleviation of side effects induced by irinotecan hydrochloride (CPT-11) in rats by intravenous infusion
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TN_cdi_proquest_journals_213447598
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_213447598
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ISSN
0344-5704
E-ISSN
1432-0843
DOI
10.1007/s00280-003-0682-0
