Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered...
Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents
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Publisher
Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Journal title
Language
English
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Publisher
Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
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Contents
Purpose Pharmacokinetic/pharmacodynamic (PK/PD) models have been shown to be useful in predicting tumor growth rates in mouse xenografts. We applied novel PK/PD models to the published anticancer combination therapies of tumor growth inhibition to simulate synergistic changes in tumor growth rates. The parameters from the PK/PD model were further u...
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Full title
Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents
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Record Identifier
TN_cdi_proquest_journals_213494501
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_213494501
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ISSN
0344-5704
E-ISSN
1432-0843
DOI
10.1007/s00280-009-1153-z
