Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human...
Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver
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Publisher
Berlin: Springer
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Language
English
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Berlin: Springer
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Contents
The enzymatic formation of 5-fluorouracil (5-FU) from two fluoropyrimidine prodrugs, doxifluridine (5'-DFUR) and tegafur (FT), was compared in vitro in order to determine whether there are differences between the metabolic profiles of the two prodrugs.
Conversion of the two fluoropyrimidine prodrugs to 5-FU was measured by high-performance liqui...
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Full title
Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver
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TN_cdi_proquest_journals_213513352
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_213513352
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ISSN
0344-5704
E-ISSN
1432-0843
DOI
10.1007/s00280-002-0528-1
