TARP Auxiliary Subunits Switch AMPA Receptor Antagonists into Partial Agonists
TARP Auxiliary Subunits Switch AMPA Receptor Antagonists into Partial Agonists
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Washington, DC: American Association for the Advancement of Science
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English
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Washington, DC: American Association for the Advancement of Science
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Quinoxalinedione compounds such as 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) are the most commonly used α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists. However, we find that in the presence of transmembrane AMPA receptor regulatory proteins (TARPs), which are AMPA receptor auxiliary subunits, CNQX acts as a parti...
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TARP Auxiliary Subunits Switch AMPA Receptor Antagonists into Partial Agonists
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TN_cdi_proquest_journals_213590578
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_213590578
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1146317
