LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake
LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake
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Washington, DC: American Association for the Advancement of Science
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English
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Washington, DC: American Association for the Advancement of Science
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Tricyclic antidepressants exert their pharmacological effect--inhibiting the reuptake of serotonin, norepinephrine, and dopamine--by directly blocking neurotransmitter transporters (SERT, NET, and DAT, respectively) in the presynaptic membrane. The drug-binding site and the mechanism of this inhibition are poorly understood. We determined the cryst...
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LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake
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TN_cdi_proquest_journals_213604352
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_213604352
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ISSN
0036-8075,0193-4511
E-ISSN
1095-9203
DOI
10.1126/science.1147614
