Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the...
Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-ζ
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Author / Creator
BEN-ROMANO, R , RUDICH, A , TIROSH, A , POTASHNIK, R , SASAOKA, T , RIESENBERG, K , SCHLAEFFER, F and BASHAN, N
Publisher
Berlin: Springer
Journal title
Language
English
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Publisher
Berlin: Springer
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Scope and Contents
Contents
Chronic exposure of 3T3-L1 adipocytes to the HIV protease inhibitor nelfinavir induces insulin resistance, recapitulating key metabolic alterations of adipose tissue in the lipodystrophy syndrome induced by these agents. Our goal was to identify the defect in the insulin signal transduction cascade leading to nelfinavir-induced insulin resistance.<...
Alternative Titles
Full title
Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-ζ
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_proquest_journals_213847712
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_213847712
Other Identifiers
ISSN
0012-186X
E-ISSN
1432-0428
DOI
10.1007/s00125-004-1408-5
