Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesoth...
Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study
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Author / Creator
van Zandwijk, Nico , Pavlakis, Nick , Kao, Steven C , Linton, Anthony , Boyer, Michael J , Clarke, Stephen , Huynh, Yennie , Chrzanowska, Agata , Fulham, Michael J , Bailey, Dale L , Cooper, Wendy A , Kritharides, Leonard , Ridley, Lloyd , Pattison, Scott T , MacDiarmid, Jennifer , Brahmbhatt, Himanshu and Reid, Glen
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publisher
England: Elsevier Ltd
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Contents
TargomiRs are minicells (EnGeneIC Dream Vectors) loaded with miR-16-based mimic microRNA (miRNA) and targeted to EGFR that are designed to counteract the loss of the miR-15 and miR-16 family miRNAs, which is associated with unsuppressed tumour growth in preclinical models of malignant pleural mesothelioma. We aimed to assess the safety, optimal dos...
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Full title
Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study
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Record Identifier
TN_cdi_proquest_journals_2138603539
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2138603539
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(17)30621-6
