Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base edi...
Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors
About this item
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Chimeric antigen receptor engineered T cell (CAR-T) immunotherapy has shown efficacy against a subset of hematological malignancies, yet its autologous nature and ineffectiveness against epithelial and solid cancers limit widespread application. To overcome these limitations, targeted nucleases have been used to disrupt checkpoint inhibitors and ge...
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Full title
Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors
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TN_cdi_proquest_journals_2139370966
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2139370966
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E-ISSN
2692-8205
DOI
10.1101/482497
How to access this item
https://www.proquest.com/docview/2139370966?pq-origsite=primo&accountid=13902
