Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Terpene synthases typically form complex molecular scaffolds by concerted activation and cyclization of linear starting materials in a single enzyme active site. Here we show that iridoid synthase, an atypical reductive terpene synthase, catalyzes the activation of its substrate 8-oxogeranial into a reactive enol intermediate, but does not catalyze...
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Full title
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis
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TN_cdi_proquest_journals_2154250005
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2154250005
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-018-0185-2
