The oncometabolite d‑2‑hydroxyglutarate induces angiogenic activity through the vascular endothelial...
The oncometabolite d‑2‑hydroxyglutarate induces angiogenic activity through the vascular endothelial growth factor receptor 2 signaling pathway
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Publisher
Athens: Spandidos Publications
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Language
English
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Athens: Spandidos Publications
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Contents
The mutation of isocitrate dehydrogenase (IDH)1 (R132H) and IDH2 (R172K) and the induction of hypoxia in various solid tumors results in alterations in metabolic profiles, including the production of the D- or l-forms of 2-hydroxyglutarate (2HG) from [alpha]-ketoglutarate in aerobic metabolism in the tricarboxylic acid (TCA) cycle. However, it is u...
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Full title
The oncometabolite d‑2‑hydroxyglutarate induces angiogenic activity through the vascular endothelial growth factor receptor 2 signaling pathway
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TN_cdi_proquest_journals_2162948869
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2162948869
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ISSN
1019-6439
E-ISSN
1791-2423
DOI
10.3892/ijo.2018.4649
