Pharmacokinetic Drug–Drug Interaction of the Novel Anticancer Agent E7070 and Acenocoumarol
Pharmacokinetic Drug–Drug Interaction of the Novel Anticancer Agent E7070 and Acenocoumarol
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Publisher
United States: Springer Nature B.V
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Language
English
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Publisher
United States: Springer Nature B.V
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Contents
E7070 is a novel sulfonamide anticancer agent that arrests cancer cells at the G1/S boundary of the cell cycle. Three patients receiving chronic therapy with the oral anticoagulant acenocoumarol experienced bleeding and/or a prolonged prothrombin time after treatment with E7070 at a dose of 700 mg/m2 given as a 1-h infusion. In vitro studies have s...
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Full title
Pharmacokinetic Drug–Drug Interaction of the Novel Anticancer Agent E7070 and Acenocoumarol
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TN_cdi_proquest_journals_216498381
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_216498381
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ISSN
0167-6997
E-ISSN
1573-0646
DOI
10.1023/B:DRUG.0000011791.75522.de
