Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference
Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Skeletal muscle mitochondria readily accumulate Ca
2+
in response to SR store-releasing stimuli thanks to the activity of the mitochondrial calcium uniporter (MCU), the highly selective channel responsible for mitochondrial Ca
2+
uptake. MCU positively regulates myofiber size in physiological conditions and counteracts pathological loss...
Alternative Titles
Full title
Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference
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TN_cdi_proquest_journals_2166350750
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2166350750
Other Identifiers
ISSN
1350-9047,1476-5403
E-ISSN
1476-5403
DOI
10.1038/s41418-018-0191-7
