Neuroprotective effect of Ligustrazine on focal cerebral ischemia injury in rats / 川芎嗪对大鼠局灶性脑缺血损伤的神经...
Neuroprotective effect of Ligustrazine on focal cerebral ischemia injury in rats / 川芎嗪对大鼠局灶性脑缺血损伤的神经保护作用
About this item
Full title
Neuroprotective effect of Ligustrazine on focal cerebral ischemia injury in rats / 川芎嗪对大鼠局灶性脑缺血损伤的神经保护作用
Publisher
Xi'an: Xi'an Jiaotong University
Journal title
Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban, 2007-01 (6), p.620
Language
Chinese
Formats
Publication information
Publisher
Xi'an: Xi'an Jiaotong University
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Scope and Contents
Contents
目的 观察川芎嗪对局灶性脑缺血后脑损伤的保护作用.方法 采用线栓法制作大鼠左侧大脑中动脉阻塞模型.氯化三苯基四氮唑(TTC)脑片染色测定脑梗死体积,干湿重法测定脑组织含水量,快速Golgi银染方法观察脑缺血周围区神经元的形态改变.结果 川芎嗪能明显缩小脑梗死体积、降低脑组织含水量,随着川芎嗪剂量增大,作用更为明显,具有剂量依赖性.脑缺血后14 d Golgi银染显示,模型组在梗死周围区神经元明显减少,变性和正常神经元共存.变性神经元主要表现为突起断裂、增粗,突起有大的串珠,树突棘减少.川芎嗪组较模型组皮质梗死周围神经元变性较少.结论 川芎嗪能缩小脑梗死体积、减轻脑水肿、保护缺血周围神经元,证实川芎嗪对脑缺血损伤有保护作用.
Alternative Titles
Full title
Neuroprotective effect of Ligustrazine on focal cerebral ischemia injury in rats / 川芎嗪对大鼠局灶性脑缺血损伤的神经保护作用
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Record Identifier
TN_cdi_proquest_journals_2182400552
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2182400552
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ISSN
1671-8259
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