Effects of tetramethylpyrazine on cell proliferation in dentate gyrus in rat brain after cerebral is...
Effects of tetramethylpyrazine on cell proliferation in dentate gyrus in rat brain after cerebral ischemia-reperfusion injury / 川芎嗪对成体大鼠脑缺血再灌注损伤后海马齿状回细胞增殖的影响
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Xi'an: Xi'an Jiaotong University
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Chinese
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Xi'an: Xi'an Jiaotong University
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目的 研究川芎嗪(tetramethylpyrazine, TMP)对大鼠脑缺血再灌注损伤后海马齿状回(dentate gyrus, DG)细胞增殖的影响.方法 成年雄性SD大鼠行2h大脑中动脉阻塞手术,术后2h开始腹腔注射TMP[40mg/(kg·d)].手术后腹腔注射5-溴脱氧尿核苷(5-bromodeoxyuridine, BrdU),末次注射24h后处死动物,免疫组化染色观察TMP对脑缺血再灌注损伤后DG细胞增殖的作用.结果 正常组和假手术组在DG有少量BrdU阳性细胞,对照组缺血后1d 阳性细胞开始增加,14d 达到高峰(P＜0.05),TMP治疗组缺血后1d损伤侧BrdU阳性细胞数开始增加,7d达高峰(P＜0.05).结论 TMP能促进缺血再灌注损伤大鼠海马齿状回内源性神经干细胞...
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Effects of tetramethylpyrazine on cell proliferation in dentate gyrus in rat brain after cerebral ischemia-reperfusion injury / 川芎嗪对成体大鼠脑缺血再灌注损伤后海马齿状回细胞增殖的影响
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TN_cdi_proquest_journals_2182404390
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2182404390
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1671-8259
