Effect of lead exposure on rat neuronal apoptosis and expression of Bcl-2 and Bax gene in hippocampu...
Effect of lead exposure on rat neuronal apoptosis and expression of Bcl-2 and Bax gene in hippocampus / 铅对大鼠海马神经细胞凋亡及Bcl-2、Bax基因表达的影响
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Xi'an: Xi'an Jiaotong University
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Chinese
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Xi'an: Xi'an Jiaotong University
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目的观察铅对大鼠学习记忆行为、海马神经元细胞凋亡及Bcl-2、Bax基因表达的影响,探讨铅对大鼠学习记忆行为及神经毒性损伤的可能机制.方法 32只SD大鼠随机分为对照组和低、中、高铅剂量组,采用自由饮水染毒90d后建立动物模型.用TUNEL法测定海马神经元细胞凋亡状况;SP免疫组织化学技术观察Bcl-2、Bax蛋白表达.结果 TUNEL染色结果显示:海马CA1、CA3、DG区各染铅组与对照组间神经元细胞凋亡指数(AI)有非常显著性差异(P<0.01).免疫组化染色结果显示,在海马CA1、CA3、DG区,Bcl-2蛋白表达阳性神经细胞均随染铅剂量增大而减少,各染铅组与对照组间有非常显著性差异(P<0.01);Bax蛋白表达阳性神经元细胞随染铅剂量增大而逐渐增多,各染铅组与对照组间比较有非常显著...
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Full title
Effect of lead exposure on rat neuronal apoptosis and expression of Bcl-2 and Bax gene in hippocampus / 铅对大鼠海马神经细胞凋亡及Bcl-2、Bax基因表达的影响
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TN_cdi_proquest_journals_2182432352
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2182432352
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1671-8259
