Rapamycin-inspired macrocycles with new target specificity
Rapamycin-inspired macrocycles with new target specificity
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Author / Creator
Guo, Zufeng , Hong, Sam Y. , Wang, Jingxin , Rehan, Shahid , Liu, Wukun , Peng, Hanjing , Das, Manisha , Li, Wei , Bhat, Shridhar , Peiffer, Brandon , Ullman, Brett R. , Tse, Chung-Ming , Tarmakova, Zlatina , Schiene-Fischer, Cordelia , Fischer, Gunter , Coe, Imogen , Paavilainen, Ville O. , Sun, Zhaoli and Liu, Jun O.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Rapamycin and FK506 are macrocyclic natural products with an extraordinary mode of action, in which they form binary complexes with FK506-binding protein (FKBP) through a shared FKBP-binding domain before forming ternary complexes with their respective targets, mechanistic target of rapamycin (mTOR) and calcineurin, respectively. Inspired by this,...
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Full title
Rapamycin-inspired macrocycles with new target specificity
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TN_cdi_proquest_journals_2184515810
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2184515810
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ISSN
1755-4330,1755-4349
E-ISSN
1755-4349
DOI
10.1038/s41557-018-0187-4
