Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment
Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Extracellular HMGB1 triggers inflammation following infection or injury, and supports tumorigenesis in inflammation-related malignancies. HMGB1 has several redox states: reduced HMGB1 recruits inflammatory cells to injured tissues forming a heterocomplex with CXCL12 and signaling via its receptor CXCR4; disulfide-containing HMGB1 binds to TLR4 and...
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Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment
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TN_cdi_proquest_journals_2187131637
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2187131637
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E-ISSN
2692-8205
DOI
10.1101/563890
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https://www.proquest.com/docview/2187131637?pq-origsite=primo&accountid=13902
