GCNA interacts with Spartan and Topoisomerase II to regulate genome stability
GCNA interacts with Spartan and Topoisomerase II to regulate genome stability
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
GCNA proteins are expressed across eukarya in pluripotent cells and have conserved functions in fertility. GCNA homologs Spartan/DVC-1 and Wss1 resolve DNA-protein crosslinks (DPCs), including Topoisomerase-DNA adducts, during DNA replication. We show that GCNA and Topoisomerase 2 (Top2) physically interact and colocalize on condensed chromosomes d...
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Full title
GCNA interacts with Spartan and Topoisomerase II to regulate genome stability
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TN_cdi_proquest_journals_2188814899
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2188814899
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E-ISSN
2692-8205
DOI
10.1101/570200
How to access this item
https://www.proquest.com/docview/2188814899?pq-origsite=primo&accountid=13902
