Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of p...
Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency
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Full title
Author / Creator
Publisher
England: Taylor & Francis
Journal title
Language
English
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Publisher
England: Taylor & Francis
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Scope and Contents
Contents
A series of nine compounds based on 3-[4-(benzyloxy)phenyl]propanoic acid core containing a 1-oxa-9-azaspiro[5.5]undecane periphery was designed, synthesized and evaluated as free fatty acid 1 (FFA1 or GPR40) agonists. The spirocyclic appendages included in these compounds were inspired by LY2881835, Eli Lilly's advanced drug candidate for type II...
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Full title
Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency
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Record Identifier
TN_cdi_proquest_journals_2195228393
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2195228393
Other Identifiers
ISSN
1475-6366
E-ISSN
1475-6374
DOI
10.1080/14756366.2016.1230110
