Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) for therapy of malignant gliomas
Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) for therapy of malignant gliomas
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United States: Springer Nature B.V
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English
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Publisher
United States: Springer Nature B.V
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The authors review the preclinical and clinical results of the ligand-targeted toxin conjugate Transferrin-CRM107 (Tf-CRM107), for the treatment of malignant gliomas. Tf-CRM107 is a conjugate protein of diphtheria toxin with a point mutation (CRM107) linked by a thioester bond to human transferrin (Tf). This conjugate exhibits potent cytotoxicity i...
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Full title
Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) for therapy of malignant gliomas
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TN_cdi_proquest_journals_219605828
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_219605828
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ISSN
0167-594X
E-ISSN
1573-7373
DOI
10.1023/a:1026246500788
