Lineage specific core-regulatory circuits determine gene essentiality in cancer cells
Lineage specific core-regulatory circuits determine gene essentiality in cancer cells
About this item
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Cancer cells rely on dysregulated gene expression programs to maintain their malignant phenotype. A cell's transcriptional state is controlled by a small set of interconnected transcription factors that form its core-regulatory circuit (CRC). Previous work in pediatric cancers has shown, that disruption of the CRC by genetic alterations causes tumo...
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Lineage specific core-regulatory circuits determine gene essentiality in cancer cells
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TN_cdi_proquest_journals_2210293032
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2210293032
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E-ISSN
2692-8205
DOI
10.1101/609552
How to access this item
https://www.proquest.com/docview/2210293032?pq-origsite=primo&accountid=13902
